News

Read about the progress of individual NINDS PDBP projects and learn about presentations and workshops that are relevant to the PDBP.

January 25, 2023

Genome-Wide Analysis of Structural Variants in Parkinson Disease

November 28, 2022

Cross-sectional Associations of β-Amyloid, Tau, and Cerebrovascular Biomarkers With Neurodegeneration in Probable Dementia With Lewy Bodies

November 22, 2022

Mass spectrometry-based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the disease

November 10, 2022

Mass spectrometry-based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways

November 9, 2022

APDM gait and balance measures fail to predict symptom progression rate in Parkinson's disease

November 8, 2022

Mitochondrial haplogroups and cognitive progression in Parkinson’s disease

September 16, 2022

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

September 1, 2022

GRN Mutations Are Associated with Lewy Body Dementia

August 27, 2022

Differences in Sex-Specific Frequency of Glucocerebrosidase Variant Carriers and Familial Parkinsonism

July 14, 2022

Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures

June 3, 2022

Association of Olfactory Performance With Motor Decline and Age at Onset in People With Parkinson Disease and the LRRK2 G2019S Variant

May 25, 2022

Dynamics of nigral iron accumulation in Parkinson’s disease: from diagnosis to late stage

May 6, 2022

Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease

April 27, 2022

Advanced diffusion imaging to track progression in Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy

April 1, 2022

Multi-modality machine learning predicting Parkinson’s disease

January 22, 2022

High-Sensitivity Single Molecule Array Assays for Pathological Isoforms in Parkinson’s Disease

January 4, 2022

Parkinson Disease and SubthalamicNucleus Deep Brain Stimulation:Cognitive Effects inGBAMutationCarriers

August 12, 2021

Longitudinal risk factors for developing depressive symptoms in Parkinson's disease

July 29, 2021

Discovery of Parkinson's disease states and disease progression modelling: a longitudinal data study using machine learning

July 27, 2021

Lateralization of Motor Signs Affects Symptom Progression in Parkinson Disease

May 6, 2021

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease

April 21, 2021

Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression

April 7, 2021

Probable REM Sleep Behavior Disorder Is a Risk Factor for Symptom Progression in Parkinson Disease

March 6, 2021

Predicting Parkinson's disease trajectory using clinical and neuroimaging baseline measures

March 4, 2021

Oral Levodopa Formulation Does Not Affect Progression of Parkinson Disease

February 20, 2021

Differential blood DNA methylation across Lewy body dementias

January 18, 2021

Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease

January 6, 2021

β-Amyloid PET and 123I-FP-CIT SPECT in Mild Cognitive Impairment at Risk for Lewy Body Dementia

Press releases, workshop summaries, and editorials

October 28, 2021

NINDS Parkinson's Disease Biomarkers Program Consortium Meeting, Bethesda MD (August 16-17, 2021)

The 2021 PDBP Annual Consortium Meeting was held virtually on August 16-17, 2021. Principal Investigators (PIs), clinical coordinators and data management experts from each PDBP project, PDBP participants and caregivers, as well as representatives from the National Institutes of Health (NIH), PD nonprofit organizations, and the pharmaceutical industry met to discuss progress over the last twelve months in addition to current and future plans for the program.

Executive Summary 2021 (PDF)

December 21, 2020

NINDS Parkinson's Disease Biomarkers Program Consortium Meeting, Bethesda MD (August 17-18, 2020)

The PDBP Annual Consortium Meeting was held as a virtual meeting on August 17-18, 2020. The meeting provided a forum for participating scientists and stakeholders to discuss recent progress and emergent opportunities in Parkinson's disease (PD), Lewy body dementia (LBD) and related Parkinsonisms biomarker research.

Executive Summary 2020 (PDF)

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