Projects We Support

The NINDS Parkinson's Disease Biomarkers Program (PDBP) supports a variety of research projects and projects that contribute to providing clinical and biospecimen resources and innovative analytical tools for PD biomarker discovery.

Active Projects

Data Types: Clinical Data Biofluid Data Imaging Data

Now entering its second 5-year renewal period.

James Leverenz
PI:
James Leverenz, MD
Cleveland Clinic

We will evaluate the ability of recently-developed research brain imaging methods to identify different types of symptoms or symptom progression in individual patients.

Kirk Frey
PI:
Kirk Frey, MD, PhD
University of Michigan

We will evaluate the ability of recently-developed research brain imaging methods to identify different types of symptoms or symptom progression in individual patients.

Now entering its second 5-year renewal period.

Brad Boeve
PI:
Brad Boeve, MD
Mayo Clinic (Rochester, Minnesota)
Kejal Kantarci
PI:
Kejal Kantarci, MD
Mayo Clinic (Rochester, Minnesota)

The goal of this project is to determine whether SPECT, PET or MRI brain imaging features predict disease progression in Dementia with Lewy Body (DLB) patients.

Nicholas Seyfried
PI:
Nicholas Seyfried, PhD
Emory University
Allan Levey
PI:
Allan Levey, MD, PhD
Emory University

Lewy body dementia (LBD) is a devastating disorder of thinking, memory, and emotional disturbances that currently has no cures or effective therapies. Novel biomarkers of LBD promise to advance our ability to manage and treat this disease. We propose to develop novel high-impact protein biomarker panels for LBD in blood and cerebrospinal fluid (CSF) using an innovative proteomic strategy that incorporates network analysis, brain- biofluid integration, and targeted biomarker validation.