NINDS Biorepositories

The NINDS Repository will facilitate the banking and distribution of biological samples collected under a standardized set of procedures designed to ensure the quality of the biospecimens collected.

Overview

In 2015, the National Institute of Neurological Disorders and Stroke (NINDS) released a funding announcement to support an independent Human Biospecimen and Data Repository for biomarkers research.  The cooperative agreement resulting from this funding announcement was awarded to Indiana University and the principal investigator for the repository is Dr. Tatiana Foroud.  The new NINDS Human Biospecimen and Data Repository is called BioSEND.  Biospecimens previously housed with the Coriell Institute for Medical Research have been transferred to BioSEND, and all biospecimens for PDBP can be queried in the PDBP Data Management Resource under the NINDS Biorepository PDBP Sample Catalog. The purpose of the repository is to receive, process, store, and distribute biospecimens resources that can be shared by the neuroscience research community, and to encourage the research efforts of established scientists, junior investigators, and scientists with novel approaches. This resource is an essential part of the infrastructure for the PDBP and will work closely with the PDBP DMR to assure standardization of biological sample collection, protection of subject privacy and rights, and transparency regarding availability of samples for Parkinson's disease biomarker discovery research.

Available Biospecimens

Pooled Biomaterial

Biospecimen pooled references have been prepared for plasma and serum, to provide researchers access to shared reference samples that can be used for normalization and standardization across sites, platforms and assays. When individual investigators assay or request access to a large number of PDBP samples (>50), they will be required to measure reference samples at the same time, so that datasets returned to the PDBP data management resource will include reference sample data for measurements of the proposed biomarkers. Should another site (Site 2) seek to replicate an observed biomarker association from an originating site (Site 1), reference samples measured at Sites 1 and 2 will provide a measure of the technical uniformity of measurements across assays and/or sites.

Interested in obtaining biospecimens?

All investigators interested in obtaining biospecimens from an NINDS biorepository must do so by submitting an order request though the Data Management Resource.